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Novel Quaternary ammonium modified-tragacanth gum hydrogels for drug delivery applications with antimicrobial activity and release kinetic study مقاله


علمی-پژوهشی (وزارت علوم) (12 صفحه - از 271 تا 282)


New antimicrobial hydrogels were prepared via reaction of functionalized-Tragacanth Gum biopolymer by glycidyltrimethylammonium chloride (QTG) with acrylamide (AM). Characterization of the QTG hydrogels with AM (QTG-AM) were carried out by thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and 1HNMR. Swelling behavior of the QTG hydrogels were investigated on the pH, medium, and temperature, immersion time. Loading and in-vitro drug release from the final hydrogels were studied by using quercetin as a model drug. Five type of kinetic models were applied, and the release of drug from the drug-loaded hydrogels occurred through non-Fickian diffusion mechanism. The water uptake by hydrogels decreased in 0.9% NaCl solution and increased in pH 9.2. The antimicrobial effect of the prepared hydrogels QTG-AM was investigated against Candida albicans, Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. The antimicrobial results demonstrated that the hydrogels possess good antimicrobial activity against the all tested microorganism.

کلیدواژه ها:

Antibacterial ، Release profile ، Drug release ، non|Fickian diffusion mechanism

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